Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetAHP-type Ca2+-activated K+ channel

General description

A polypeptide neurotoxin known to pass through the blood-brain barrier. Blocks the AHP-type Ca²⁺-activated K⁺ channel; however, it does not block the TEA and voltage-sensitive Ca²⁺-activated K⁺ channel. Known to induce the secretion of prolactin in a dose-dependent manner.

Polypeptide neurotoxin known to pass through the blood-brain barrier. Blocks the AHP-type Ca²⁺-activated K⁺ channel; does not block the TEA and voltage-sensitive Ca²⁺-activated K⁺ channel. Reported to induce neurodegeneration of Purkinje cells in rat brain. Known to induce the secretion of prolactin in a dose-dependent manner.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Mourre, C., et al. 1997. Brain Res. 778, 405.Silva, E.G., et al. 1994. Br. J. Pharmacol. 113, 1022.Wang, X., et al. 1994. Brain Res. 662, 83.

Packaging

500 µg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Acetic acid stock solutions are stable for up to 3 days at -20°C.

Sequence

H-Cys¹-Asn-Cys³-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys¹¹-Ala-Arg-Arg-Cys¹⁵-Gln-Gln-His-NH₂ (disulfide bonds: 1 → 11; 3 → 15)

Warning

Toxicity: Harmful (C)